Pharmaceutical Development of Oxaloacetate

Modification of Cellular Metabolism to Ameliorate Pathological Fatigue

MetVital is a clinical-stage, metabolic therapy company developing first-in-class, broadly applicable methods to improve cellular metabolism to address fatigue in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), Long COVID, Cancer Related Fatigue (CRF), Amyotrophic Lateral Sclerosis (ALS) and Parkinson’s Disease.

MetVital has developed and patented a small molecule “AEO” that moves metabolism towards the “Normal” state instead of a “Fatigued” state. Multiple mechanisms improve fatigue:

Reduction of Chronic Inflammation Activation Via NF-kB Reduction of up to 70%

Wilkins HM, Harris JL, Carl SM, et al. Oxaloacetate activates brain mitochondrial biogenesis, enhances the insulin pathway, reduces inflammation and stimulates neurogenesis. Hum Mol Genet. 2014;23(24):6528-6541. doi:10.1093/hmg/ddu371 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4271074/

Reduction of Glycolysis/Warburg Effect 48.8% and Increased Mitochondrial Energy Production

Omkar Ijare, David Conway, Alan Cash, David Baskin, Kumar Pichumani, CBMT-49. OXALOACETATE ALTERS GLUCOSE METABOLISM IN GLIOBLASTOMA: 13C ISOTOPOMER STUDY, Neuro-Oncology, Volume 21, Issue Supplement_6, November 2019, Pages vi43–vi44, https://doi.org/10.1093/neuonc/noz175.171 https://academic.oup.com/neuro-oncology/article-abstract/21/Supplement_6/vi43/5620031?redirectedFrom=fulltext

Increase in the Redox NAD+/NADH Ratio by 50%

Wilkins HM, Harris JL, Carl SM, et al. Oxaloacetate activates brain mitochondrial biogenesis, enhances the insulin pathway, reduces inflammation and stimulates neurogenesis. Hum Mol Genet. 2014;23(24):6528-6541. doi:10.1093/hmg/ddu371 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4271074/

Increase in PGC1a ratio by 58% to Facilitate Mitochondrial Biogenesis, Providing More Cellular Power Plants.

Wilkins HM, Harris JL, Carl SM, et al. Oxaloacetate activates brain mitochondrial biogenesis, enhances the insulin pathway, reduces inflammation and stimulates neurogenesis. Hum Mol Genet. 2014;23(24):6528-6541. doi:10.1093/hmg/ddu371 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4271074/

Increase in Cellular Glucose Uptake, Providing More Fuel for the Cell

Yoshikawa K. Studies on the anti-diabetic effect of sodium oxaloacetate. Tohoku J Exp Med. 1968 Oct;96(2):127-41. doi: 10.1620/tjem.96.127. PMID: 4884771. https://pubmed.ncbi.nlm.nih.gov/4884771/