/* Page sections and content components. */
.section { padding: clamp(4rem, 9vw, 7.5rem) 0; }
.section--tight { padding: clamp(3rem, 6vw, 4.5rem) 0 clamp(4rem, 8vw, 6rem); }
.split { display: grid; grid-template-columns: 5fr 7fr; gap: clamp(2rem, 5vw, 5rem); align-items: start; }
.split--end { align-items: end; grid-template-columns: 1fr auto; margin-bottom: 2.5rem; }
.prose-lg { font-size: 1.12rem; color: var(--ink-2); }
@media (max-width: 860px) { .split, .split--end { grid-template-columns: 1fr; } }

/* Home hero */
.research-announcement { padding-bottom: 0; }
.announcement-card { border: 1px solid var(--line); border-top: 4px solid var(--accent); border-radius: var(--radius); background: var(--ice); padding: clamp(1.4rem, 4vw, 3rem); }
.announcement-card h2 { max-width: 34ch; font-size: clamp(1.7rem, 3vw, 2.5rem); }
.announcement-lede { max-width: 75ch; font-size: 1.15rem; color: var(--ink-2); }
.announcement-copy { max-width: 85ch; color: var(--ink-2); }
.announcement-links-label { margin-top: 1.8rem; font-weight: 600; }
.announcement-disclaimer { margin: 2rem 0 0; padding-top: 1.5rem; border-top: 1px solid var(--line); font-size: .9rem; line-height: 1.65; color: var(--muted); }
.hero { position: relative; overflow: hidden; background: var(--ice); padding: clamp(3.5rem, 8vw, 6.5rem) 0 4.5rem; isolation: isolate; }
.hero-media { position: absolute; inset: 0 0 0 auto; width: min(62%, 860px); z-index: -2; }
.hero-media img { width: 100%; height: 100%; object-fit: cover; object-position: 70% 60%; filter: grayscale(1); animation: drift 24s ease-in-out infinite alternate; }
.hero::before { content: ''; position: absolute; inset: 0; z-index: -1; background: linear-gradient(90deg, var(--ice) 34%, rgba(244, 244, 244, .9) 52%, rgba(244, 244, 244, .2) 78%, rgba(244, 244, 244, 0)); }
.hero::after { content: ''; position: absolute; right: 0; bottom: -1px; width: 38%; height: 120px; background: var(--paper); clip-path: polygon(100% 0, 100% 100%, 0 100%); z-index: -1; }
@keyframes drift { to { transform: scale(1.06) translateX(-1.5%); } }
.hero-grid { display: grid; grid-template-columns: 1.15fr .85fr; gap: 2rem; align-items: center; }
.hero h1 { font-size: clamp(2.4rem, 5vw, 3.9rem); max-width: 15ch; margin-bottom: .35em; }
.hero-company { font: 600 1.15rem/1.3 var(--display); color: var(--blue); margin-bottom: 1.4rem; }
.hero .lede { max-width: 50ch; }
.img-note { font: 400 .68rem/1 var(--mono); letter-spacing: .08em; color: var(--muted); text-align: right; margin: 2.2rem auto 0; }
@media (max-width: 900px) {
  .hero-grid { grid-template-columns: 1fr; }
  .hero-media { width: 100%; opacity: .35; }
  .hero::before { background: linear-gradient(180deg, rgba(244, 244, 244, .92), rgba(244, 244, 244, .8)); }
  .hero-cycle { max-width: 380px; margin-inline: auto; }
}

/* Citric-acid cycle figure */
.cycle { margin: 0; }
.cycle svg { width: 100%; height: auto; overflow: visible; }
.cycle .ring { fill: none; stroke: var(--ink-3); stroke-opacity: .28; stroke-width: 1.2; }
.cycle .ring--flow { stroke: var(--blue); stroke-opacity: .9; stroke-width: 2; stroke-dasharray: 60 882; stroke-linecap: round; transform-origin: 200px 200px; animation: flow 9s linear infinite; }
.cycle .core { fill: rgba(255, 255, 255, .75); stroke: var(--line); }
.cycle .core-t { font: 500 13px var(--mono); fill: var(--muted); letter-spacing: .04em; }
.cycle .node circle { fill: var(--paper); stroke: var(--ink-3); stroke-width: 1.5; }
.cycle .node text { font: 500 12.5px var(--body); fill: var(--ink-2); }
.cycle .node--key circle { fill: var(--amber); stroke: var(--amber); }
.cycle .node--key .halo { fill: none; stroke: var(--amber); stroke-opacity: .5; transform-box: fill-box; transform-origin: center; animation: pulse 3s var(--ease) infinite; }
.cycle .node--key text { font: 700 15px var(--display); fill: var(--ink); }
@keyframes flow { to { transform: rotate(360deg); } }
@keyframes pulse { 0% { transform: scale(.6); opacity: 1; } 100% { transform: scale(1.6); opacity: 0; } }

/* Quick links strip (overlaps hero) */
.quicklinks { position: relative; z-index: 2; margin-top: -2.4rem; display: grid; grid-template-columns: repeat(3, 1fr); background: var(--paper); border: 1px solid var(--line); border-radius: var(--radius); box-shadow: var(--shadow); }
.quicklinks a { display: grid; grid-template-columns: 1fr auto; align-items: center; column-gap: 1rem; padding: 1.25rem 1.5rem; text-decoration: none; color: var(--ink); transition: background .25s; }
.quicklinks a + a { border-left: 1px solid var(--line); }
.quicklinks a:hover { background: var(--ice); }
.quicklinks a:hover .i { transform: translateX(4px); color: var(--amber); }
.quicklinks .i { grid-row: span 2; color: var(--blue); transition: transform .25s var(--ease), color .25s; }
.ql-k { font: 500 .68rem/1.4 var(--mono); letter-spacing: .14em; text-transform: uppercase; color: var(--muted); }
.ql-t { font: 600 1rem/1.3 var(--display); }
@media (max-width: 760px) { .quicklinks { grid-template-columns: 1fr; } .quicklinks a + a { border-left: 0; border-top: 1px solid var(--line); } }

/* Relationship */
.relation { background: var(--paper); border-top: 1px solid var(--line); }
.rel-grid { display: grid; grid-template-columns: 1fr auto 1fr; gap: 0; align-items: stretch; margin-top: 2.5rem; }
.rel-card { padding: 2.2rem; border: 1px solid var(--line); border-radius: var(--radius); background: var(--paper); transition: transform .35s var(--ease), box-shadow .35s; }
.rel-card:hover { transform: translateY(-3px); box-shadow: var(--shadow); }
.rel-card--mv { background: var(--ink); border-color: var(--ink); color: #dddddd; }
.rel-card--mv h3 { color: var(--paper); }
.rel-card--mv .rel-focus { color: #ffffff; }
.rel-tag { font: 500 .68rem/1 var(--mono); letter-spacing: .16em; text-transform: uppercase; color: var(--muted); }
.rel-card--mv .rel-tag { color: #cccccc; }
.rel-card h3 { font-size: 1.5rem; margin-bottom: .35rem; }
.rel-focus { font: 600 .95rem/1.4 var(--display); color: var(--blue); margin-bottom: 1.2rem; }
.rel-bridge { position: relative; width: 120px; display: grid; place-items: center; }
.rel-bridge::before { content: ''; position: absolute; left: 0; right: 0; top: 50%; border-top: 1px dashed var(--ink-3); opacity: .5; }
.rel-bridge span { position: relative; background: var(--paper); font: 500 .62rem/1.4 var(--mono); text-transform: uppercase; letter-spacing: .1em; color: var(--muted); text-align: center; padding: .4rem; max-width: 100px; }
.rel-closing { max-width: 64ch; margin: 2.5rem auto 0; text-align: center; font-size: 1.08rem; color: var(--ink-2); }
@media (max-width: 860px) {
  .rel-grid { grid-template-columns: 1fr; }
  .rel-bridge { width: auto; height: 70px; }
  .rel-bridge::before { left: 50%; right: auto; top: 0; bottom: 0; border-top: 0; border-left: 1px dashed var(--ink-3); }
}

/* Research areas */
.research { background: var(--ice); }
.research--pale { background: var(--ice); }
.pipeline-research-intro { max-width: 78ch; }
.areas { list-style: none; padding: 0; margin: 3.5rem 0 0; display: grid; grid-template-columns: repeat(2, 1fr); gap: 1px; background: var(--line); border: 1px solid var(--line); border-radius: var(--radius); overflow: hidden; }
.area { position: relative; background: var(--paper); padding: 2.2rem 2.2rem 2rem 5.2rem; transition: background .3s; }
.area:hover { background: #faf7f7; }
.area-n { position: absolute; left: 2rem; top: 2.15rem; font: 500 .8rem/1 var(--mono); color: var(--amber); }
.area-n::after { content: ''; display: block; width: 6px; height: 6px; border-radius: 50%; border: 1.5px solid var(--amber); margin-top: .7rem; transition: background .3s, transform .3s var(--ease); }
.area:hover .area-n::after { background: var(--amber); transform: scale(1.4); }
.area h3 { font-size: 1.2rem; }
.area p { margin: 0; color: var(--muted); }
.closing-line { margin: 2.5rem 0 0; font: 500 1.2rem/1.5 var(--display); color: var(--ink); max-width: 46ch; border-left: 3px solid var(--amber); padding-left: 1.2rem; }
@media (max-width: 760px) { .areas { grid-template-columns: 1fr; } .area { padding: 1.8rem 1.5rem 1.6rem 4rem; } .area-n { left: 1.4rem; } }

/* Evidence / legacy citations */
.evidence-head { max-width: 640px; margin-bottom: 3rem; }
.evidence-body { columns: 2 380px; column-gap: 3.5rem; color: var(--ink-2); }
.evidence-body > * { break-inside: avoid; }
.evidence-body h2 { column-span: all; font-size: 1.3rem; max-width: 52ch; margin: 2rem 0 1.5rem; padding-top: 2rem; border-top: 1px solid var(--line); }
.evidence-body img { width: 160px; margin: 1.2rem 0; mix-blend-mode: multiply; }
.evidence-intro { column-span: all; display: grid; align-items: center; gap: 1rem; }
.evidence-intro p { margin: 0; }
.evidence-molecule { display: flex; align-items: center; justify-content: center; margin: 0; padding: 0; }
.evidence-molecule img { width: 220px; height: auto; margin: 0; }
@media (min-width: 1024px) {
  .evidence-intro + h2 { margin-inline: auto; text-align: center; }
}
.evidence-body h3 { font-size: 1.05rem; margin: 1.8rem 0 .5rem; padding-left: 1rem; border-left: 2px solid var(--blue); }
.evidence-body h3 i { font-style: normal; }
.evidence-body p { font-size: .97rem; }
.evidence-body p em, .evidence-body p:has(a) { font: 400 .8rem/1.6 var(--mono); color: var(--muted); font-style: normal; }
.legacy a { word-break: break-word; }

/* Leaders */
.leaders { background: var(--paper); border-top: 1px solid var(--line); }
.leader-row { display: grid; grid-template-columns: repeat(2, 1fr); gap: 1.5rem; }
.leader-card { display: grid; grid-template-columns: 150px 1fr; gap: 1.6rem; align-items: center; padding: 1.25rem; border: 1px solid var(--line); border-radius: var(--radius); text-decoration: none; color: var(--ink); transition: border-color .3s, box-shadow .3s, transform .3s var(--ease); }
.leader-card:hover { border-color: var(--blue); box-shadow: var(--shadow); transform: translateY(-3px); color: var(--ink); }
.leader-photo { overflow: hidden; border-radius: 4px; background: var(--ice); aspect-ratio: 3 / 4; }
.leader-photo img { width: 100%; height: 100%; object-fit: cover; filter: grayscale(1) contrast(1.04); transition: transform .6s var(--ease); }
.leader-card:hover .leader-photo img { transform: scale(1.04); }
.leader-meta { display: grid; gap: .3rem; }
.leader-name { font: 700 1.35rem/1.2 var(--display); }
.leader-role { color: var(--muted); margin-bottom: .8rem; }
@media (max-width: 860px) { .leader-row { grid-template-columns: 1fr; } .leader-card { grid-template-columns: 110px 1fr; } }

/* Collaboration band */
.collab { background: var(--ink); color: #dddddd; padding: clamp(4rem, 9vw, 7rem) 0; }
.collab h2 { color: var(--paper); font-size: clamp(2rem, 4vw, 3rem); max-width: 14ch; }
.collab-grid { display: grid; grid-template-columns: 5fr 7fr; gap: clamp(2rem, 6vw, 6rem); }
.collab-copy { font-size: 1.08rem; }
.sister-note { margin-top: 2rem; padding-top: 1.4rem; border-top: 1px solid rgba(221, 221, 221, .18); font-size: .93rem; color: #cccccc; }
.sister-note a { color: #ffffff; }
.sister-note--dark { border-color: var(--line); color: var(--muted); }
.sister-note--dark a { color: var(--blue); }
@media (max-width: 860px) { .collab-grid { grid-template-columns: 1fr; } }

/* Interior page hero */
.page-hero { position: relative; overflow: hidden; background: var(--ice); padding: 2.2rem 0 clamp(3rem, 6vw, 4.5rem); border-bottom: 1px solid var(--line); isolation: isolate; }
.page-hero-bg { position: absolute; inset: 0 0 0 auto; width: 46%; z-index: -1; background: url('/images/metvital-laboratory-hero.jpg') 80% 65% / cover; filter: grayscale(1); opacity: .55; -webkit-mask-image: linear-gradient(90deg, transparent, #000 70%); mask-image: linear-gradient(90deg, transparent, #000 70%); }
.page-hero h1 { max-width: 20ch; margin-bottom: .5em; }
.page-hero--compact h1 { font-size: clamp(1.7rem, 3.2vw, 2.5rem); max-width: 34ch; }
.crumbs ol { list-style: none; display: flex; flex-wrap: wrap; gap: .4rem; margin: 0 0 2.4rem; padding: 0; font: 400 .74rem/1.4 var(--mono); color: var(--muted); }
.crumbs li { max-width: 46ch; overflow: hidden; text-overflow: ellipsis; white-space: nowrap; }
.crumbs li + li::before { content: '/'; margin-right: .4rem; color: var(--line); }
.crumbs a { color: var(--muted); text-decoration: none; }
.crumbs a:hover { color: var(--blue); }
@media (max-width: 760px) { .page-hero-bg { width: 100%; opacity: .2; } }

/* Prose */
.reading { max-width: 760px; }
.reading--aside { max-width: none; display: grid; grid-template-columns: minmax(0, 1fr) 300px; gap: clamp(2rem, 5vw, 4.5rem); align-items: start; }
.prose { color: var(--ink-2); max-width: 68ch; }
.prose h2 { font-size: 1.45rem; margin-top: 2.2rem; }
.prose h3, .prose h4 { font-size: 1.12rem; margin-top: 1.8rem; }
.prose ul, .prose ol { padding-left: 1.2rem; margin: 0 0 1.2em; }
.prose li { margin-bottom: .55em; }
.prose li::marker { color: var(--amber); }
.prose strong { color: var(--ink); }
.byline { display: flex; flex-wrap: wrap; gap: .4rem 1.2rem; font: 400 .78rem/1.4 var(--mono); color: var(--muted); padding-bottom: 1.2rem; margin-bottom: 1.8rem; border-bottom: 1px solid var(--line); }
.byline time { color: var(--amber); font-weight: 500; }
.side-card { position: sticky; top: 100px; padding: 1.6rem; background: var(--ice); border: 1px solid var(--line); border-radius: var(--radius); }
.side-card .eyebrow { margin-bottom: .7rem; }
.side-card--list ul { list-style: none; margin: 0 0 1.2rem; padding: 0; }
.side-card--list li + li { border-top: 1px solid var(--line); }
.side-card--list li a { display: block; padding: .9rem 0; font: 600 .88rem/1.4 var(--display); color: var(--ink); text-decoration: none; transition: color .2s; }
.side-card--list li a:hover { color: var(--blue); }
.side-card--list .post-date { display: block; margin-bottom: .25rem; }
.aside-phone { font: 400 .85rem var(--mono); color: var(--muted); margin: .9rem 0 0; }
@media (max-width: 900px) { .reading--aside { grid-template-columns: 1fr; } .side-card { position: static; } }

/* Personnel */
.people { padding: clamp(3rem, 6vw, 5rem) 0; display: grid; gap: clamp(3rem, 7vw, 6rem); }
.person { display: grid; grid-template-columns: 300px minmax(0, 1fr); gap: clamp(2rem, 6vw, 5rem); align-items: start; scroll-margin-top: 110px; }
.person + .person { padding-top: clamp(3rem, 7vw, 6rem); border-top: 1px solid var(--line); }
.person-side { position: sticky; top: 100px; display: grid; gap: 1.5rem; }
.portrait { position: relative; border-radius: var(--radius); overflow: hidden; background: var(--ice); aspect-ratio: 215 / 300; }
.portrait::after { content: ''; position: absolute; inset: 0; box-shadow: inset 0 0 0 1px rgba(49, 49, 49, .08); border-radius: inherit; }
.portrait img { width: 100%; height: 100%; object-fit: cover; filter: grayscale(1); }
.facts h3 { font: 500 .68rem/1.4 var(--mono); letter-spacing: .14em; text-transform: uppercase; color: var(--amber); margin-bottom: .6rem; }
.facts ul { list-style: none; margin: 0; padding: 0; display: flex; flex-wrap: wrap; gap: .4rem; }
.facts li { font-size: .8rem; line-height: 1.35; padding: .35rem .6rem; background: var(--ice); border: 1px solid var(--line); border-radius: 3px; color: var(--ink-2); }
.person-main h2 { font-size: clamp(2rem, 4vw, 2.8rem); }
.person-main .dash, .person-main .role-inline { position: absolute; width: 1px; height: 1px; overflow: hidden; clip: rect(0 0 0 0); }
.person-main .prose p:first-child { font-size: 1.2rem; color: var(--ink); }
@media (max-width: 860px) { .person { grid-template-columns: 1fr; } .person-side { position: static; grid-template-columns: 160px 1fr; } .person-side .facts { grid-column: 1 / -1; } }

/* Pipeline */
.pipe-grid { display: grid; grid-template-columns: minmax(0, 1fr) 320px; gap: clamp(2rem, 5vw, 4rem); align-items: center; }
.diagram-frame { margin: 0; padding: clamp(1rem, 3vw, 2rem); background: var(--paper); border: 1px solid var(--line); border-radius: var(--radius); box-shadow: var(--shadow); }
.diagram-frame img { margin-inline: auto; }
.pipe-aside h2 { font-size: 1.6rem; }
@media (max-width: 900px) { .pipe-grid { grid-template-columns: 1fr; } }

/* Contact */
.contact-grid { display: grid; grid-template-columns: 1fr 1fr; gap: clamp(2rem, 5vw, 4.5rem); align-items: start; }
.contact-card { background: var(--paper); border: 1px solid var(--line); border-radius: var(--radius); box-shadow: var(--shadow); overflow: hidden; padding-bottom: 1rem; }
.contact-card img { width: 100%; aspect-ratio: 16 / 7; object-fit: cover; filter: grayscale(1); }
.contact-card h2 { font: 500 .72rem/1 var(--mono); letter-spacing: .16em; text-transform: uppercase; color: var(--amber); margin: 1.8rem 1.8rem 1rem; }
.contact-card p { margin: 0 1.8rem; padding: 1rem 0; border-top: 1px solid var(--line); display: grid; grid-template-columns: 110px 1fr; gap: 1rem; }
.contact-card p br:first-of-type { display: none; }
.contact-card strong { font: 600 .82rem/1.6 var(--display); color: var(--muted); }
.contact-card a { color: var(--ink); text-decoration: none; }
.contact-card a:hover { color: var(--blue); text-decoration: underline; }
.contact-side h2 { font-size: 1.8rem; }
@media (max-width: 860px) { .contact-grid { grid-template-columns: 1fr; } }

/* Press listings */
.posts { list-style: none; margin: 0; padding: 0; border-top: 1px solid var(--line); }
.post { border-bottom: 1px solid var(--line); }
.post a { display: grid; grid-template-columns: 170px minmax(0, 1fr); gap: .4rem 2.5rem; padding: 2rem .75rem; text-decoration: none; color: var(--ink); transition: background .3s; }
.post a:hover { background: var(--ice); }
.post-date { font: 500 .76rem/1.6 var(--mono); color: var(--amber); letter-spacing: .04em; }
.post-date, .post .link-more { grid-column: 1; }
.post .post-date { grid-row: 1 / span 3; padding-top: .2rem; }
.post-title, .post-sum, .post .link-more { grid-column: 2; }
.post-title { font: 600 1.25rem/1.35 var(--display); max-width: 60ch; }
.post-sum { color: var(--muted); font-size: .93rem; }
@media (max-width: 700px) { .post a { grid-template-columns: 1fr; } .post .post-date, .post-title, .post-sum, .post .link-more { grid-column: 1; grid-row: auto; } }

/* Search results */
.search-results { padding: clamp(3rem, 6vw, 5rem) 0; }
.search-results h1 { font-size: clamp(1.8rem, 3.4vw, 2.6rem); outline: none; }
.search-results [role="status"] { font: 400 .82rem var(--mono); color: var(--muted); }
.result { padding: 1.6rem 0; border-top: 1px solid var(--line); }
.result h2 { font-size: 1.2rem; margin-bottom: .4rem; }
.result h2 a { text-decoration: none; }
.result p { color: var(--muted); margin: 0; font-size: .95rem; }
.result mark { background: var(--amber-soft); color: var(--ink); padding: 0 .1em; }