MetVital, Inc.
MetVital, Inc. is an independently owned research and drug development company dedicated to advancing scientific understanding of oxaloacetate and investigating its potential applications in human health.
Special announcement
Independent research explores oxaloacetate in breast cancer survivors experiencing cognitive difficulties following treatment.
Researchers at the UCLA Health Jonsson Comprehensive Cancer Center have published a Phase II clinical study in JCO Oncology Advances examining oxaloacetate and cognitive function in breast cancer survivors.
The eight-week study reported statistically significant improvements in participant-reported cognitive symptoms, along with improvements in fatigue and physical functioning.
Terra Biological, the company behind benaGene and Oxaloacetate CFS, supplied the thermally stabilized oxaloacetate formulation used in this independent research. Terra Biological did not sponsor or author the study.
The findings are preliminary, and additional placebo-controlled clinical research is needed to determine whether oxaloacetate caused the reported improvements.
Explore the research:
Research Disclaimer: This information is provided for scientific and educational purposes only. The UCLA study evaluated an investigational use of oxaloacetate and does not establish that benaGene or Oxaloacetate CFS is effective for cancer-related cognitive impairment or any other condition studied in this research. Neither product is FDA-approved to treat cancer-related cognitive impairment. The research does not constitute an endorsement of these products by UCLA.
Overview
MetVital builds upon two decades of research into cellular metabolism, energy regulation, and the biological pathways associated with aging and disease.
Our work focuses on exploring new clinical applications of the metabolite oxaloacetate, supporting scientific investigations, and collaborating with academic and medical research institutions to advance promising drug discoveries.
Sister companies, distinct missions
Scientific research and drug development
While Terra Biological focuses on bringing research-based products to market, MetVital operates as a separate company dedicated to scientific research and drug development, and the exploration of new applications for oxaloacetate for the treatment of disease.
Separate company
Oxaloacetate-based nutritional supplements and medical foods
MetVital, Inc. is a sister company to Terra Biological LLC, a San Diego-based company specializing in the development and commercialization of oxaloacetate-based nutritional supplements and medical foods.
Visit terrabiological.comThe two companies share a common scientific foundation and a commitment to advancing oxaloacetate research while maintaining their distinct corporate identities and operations.
Our Research Focus
Oxaloacetate is a naturally occurring compound involved in cellular energy metabolism and the citric acid cycle.
Early investigations into oxaloacetate focused on its potential to influence metabolic pathways associated with caloric restriction and healthy aging.
Building upon this foundational research, MetVital is interested in advancing scientific investigations across several areas, including:
Investigating the biological mechanisms through which oxaloacetate influences cellular energy pathways.
Supporting research into oxaloacetate's potential applications in reducing ME/CFS, Long COVID Cancer Related Cognitive Impairment and ALS.
Exploring oxaloacetate's potential role in cognitive health, including cognitive difficulties experienced following cancer treatment or viral infections.
Identifying additional opportunities for rigorous scientific investigation and future clinical development.
Our objective is to advance research through scientifically sound methodologies, academic collaboration, and the continued evaluation of clinical evidence.
From the published record
Previously published on metvital.com, reproduced with its original references and links.
MetVital is a clinical-stage, metabolic therapy company developing first-in-class, broadly applicable methods to improve cellular metabolism to address fatigue in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), Long COVID, Cancer Related Fatigue (CRF), Amyotrophic Lateral Sclerosis (ALS) and Parkinson’s Disease.
Wilkins HM, Harris JL, Carl SM, et al. Oxaloacetate activates brain mitochondrial biogenesis, enhances the insulin pathway, reduces inflammation and stimulates neurogenesis. Hum Mol Genet. 2014;23(24):6528-6541. doi:10.1093/hmg/ddu371 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4271074/
Omkar Ijare, David Conway, Alan Cash, David Baskin, Kumar Pichumani, CBMT-49. OXALOACETATE ALTERS GLUCOSE METABOLISM IN GLIOBLASTOMA: 13C ISOTOPOMER STUDY, Neuro-Oncology, Volume 21, Issue Supplement_6, November 2019, Pages vi43–vi44, https://doi.org/10.1093/neuonc/noz175.171 https://academic.oup.com/neuro-oncology/article-abstract/21/Supplement_6/vi43/5620031?redirectedFrom=fulltext
Wilkins HM, Harris JL, Carl SM, et al. Oxaloacetate activates brain mitochondrial biogenesis, enhances the insulin pathway, reduces inflammation and stimulates neurogenesis. Hum Mol Genet. 2014;23(24):6528-6541. doi:10.1093/hmg/ddu371 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4271074/
Wilkins HM, Harris JL, Carl SM, et al. Oxaloacetate activates brain mitochondrial biogenesis, enhances the insulin pathway, reduces inflammation and stimulates neurogenesis. Hum Mol Genet. 2014;23(24):6528-6541. doi:10.1093/hmg/ddu371 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4271074/
Yoshikawa K. Studies on the anti-diabetic effect of sodium oxaloacetate. Tohoku J Exp Med. 1968 Oct;96(2):127-41. doi: 10.1620/tjem.96.127. PMID: 4884771. https://pubmed.ncbi.nlm.nih.gov/4884771/
Leadership
Looking Ahead
MetVital is committed to furthering scientific understanding of oxaloacetate and exploring opportunities for future clinical development.
We welcome opportunities to collaborate with academic institutions, clinical investigators, and organizations interested in advancing rigorous research into the potential applications of oxaloacetate.
Our mission is to contribute to meaningful scientific progress through research, innovation, and collaboration.
Learn more about our sister company: Terra Biological LLC
